No, Sakura really cant.....

For one shes not related to any strong ninja, let alone someone like the First Hokage. Shes not talented like Tsunade was at her age (Tsunade got one of the bells from the Third during there survival training, Sakura just screamed alot), and Sakura doesnt do anything except yell "Sasuke-kun!" every five seconds. And the way things look, I certainly dont think Tsunade ever had a crush on Orochimaru, as your analogy would take things.

The only similarities is that they were on a team with two really strong male ninja, had a very strong sensei, and....yeah, thats about it. Ton Ton has a better chance at becoming Hokage than Sakura.