No one has ever looked down on Tsunade. She always had her strong presence and reputation. At least she had respect because she was the 1st hokage's granddaughter.
Jiraiya is the one who both Tsu and Oro look down onto. Even now when they are older, Oro shows respect to Tsunade and even fears her to some degree (he said that one punch from her can kill), but Oro still looks down on Jiraiya and calls him an idiot. Jiraiya showed great respect to Tsunade and considered her better than him as a hokage.

My point is Sakura is nothing like Tsunade. Tsunade has always been one of the superior ninjas even when she was a little girl. At least she was able to get the bell from the 3rd in the bell training, where Sakura didn't even touch Kakashi's bell and we know how the 3rd is superior to Kakashi.

In simple words, Sakura sucks... Tsunade rules.