I just had to comment on this thread, usually I just lurk but you guys are forgetting a major point.

The only way to remove the curse is death, then after the curse seals up along with the secret of the Byuakugan(sp?). So the only way Neji can escape his destiny is death. But that is part of his destiny so all in all, he will be bound to his destiny forever. He may work hard and surpass the main family but he'll still have the curse and he'll have it his whole life. No matter how hard he works, Neji can never free himself from his cage.