Things I'm guaranteed to watch:
Shinryaku!? Ika Musume
Bakuman. 2nd Series
WORKING!!
Fate/Zero
Mirai Nikki (though I am prepared to drop this at any time if it doesn't seem like it is living up to the source, or if my interest begins to wane, as it did with the manga)
Persona 4
Things I'll give a shot:
Kyoukai Senjou no Horizon (I thought the premise sounded interesting for months since the initial announcement, I'm interested in what they do with this. A sort of futuristic medieval era.)
Tamayura ~hitotose~ (slice of life, ARIA staff? I am there.)
Chihayafuru (this actually sound really interesting for some reason. The premise sounds silly, but the RandomC preview hints at enough fully developed background for the characters that some good development and personality might shine through.)
Boku wa Tomodachi ga Sukunai (meh...but at least the cast is good, and it looks better than the rest of similar offerings.)
Last Exile -Ginyoku no Fam- (I'm leery about GONZO, particularly when they're trying to revive themselves by dredging up old titles, but for every two bleh series, they also can produce compelling original work/adapations. I'm not sure I like the "turn the entire cast into moe girls" though...that seems like a big hit against it.)
Ben-To (sounds stupid, but it gets MAJOR points for originality. Could be a really great comedy if they play it ultra-serious and over the top.)
Guilty Crown (really strong casting, decent enough premise, macross parallels? Definitely give it a shot.)
What I'm really liking about this season is how many of the series starting this season are slated for 24-26 episodes.