IMO, Naruto/Sakura would just feel... weird. If she hadn't shown so much tears and crap for Sasuke, then maybe, but the series has such a solid base on Sakura's mad crush on Sasuke, it's really hard for me to think it can easily be turned around. It also has a very solid base on Hinata's crush on Naruto (ever since her character was introduced), while Naruto has not shown any signs (that I remember) of still having a crush on Sakura since Sasuke left, which was also when Sakura showed the most emotions towards Sasuke, even offering to basically turn to the dark side along with him. Powerful stuff if you ask me.
To think that all of the above can be easily thrown in the garbage and start new, I think it's stupid. Plus, hooking up with a girl that had a mad crush on your best friend isn't healthy.
Ranting aside, I cant wait to see how the battle with Bee/Kisame pans out. I gotta admit, I've never been a fan of Kisame. I thought it was one of the crappiest characters, due to his "monster" appearance. Now It feels like his appearance could've changed because of Samehada. Maybe because of fusing with it? Or maybe because of the chakra exchanges between them? Interesting stuff.