Quote Originally Posted by digitalrurouni
So between the first anime and the manga, where exactly did they go their separate ways? Curious minds want to know!
dubious grounds for potential spoilers, but...

about episode 28 (where Izumi puts Ed and Al on the training island again and they encounter Wrath) is where the anime deviates from the manga. From that point there are maybe two or three things from the manga that are implemented in the anime, but, for the most part, it's all completely different