Hmm you really think Sasuke will go after tsunade because she's the hokage? i mean he does seem to want to keep the casualties to a minimum and since tsunade probably didn't even know of the uchiha situation until she became hokage i don't see sasuke going specifically after her. Then again Madara would absolutely own Tsunade wouldn't he? She relies mostly on phisical attacks and with his time space jutsu tsunade wouldn't last 5 minutes.

But i do have to say that i'm curious as to just how strong the elders really are, they've also been trained by the second hokage after all.