I've never played the game, but this looks like kickass movie. It stars Timothy Olyphant (Deadwood, Live Free or Die Hard) as Agent 47. I think he'll do great.
Here's an interview with Timothy, and it includes a bit of info on Deadwood for those interested:
http://www.tv.com/story/10172.html
This page has some trailers:A gun-for-hire known only as Agent 47 (Olyphant) is ensnared in a political conspiracy, which finds him pursued by both Interpol and the Russian military as he treks across Eastern Europe. hired by a group known as "The Agency" to kill targets for cash.
http://www.filmspot.com/movie/363577/hitman/index.html