Whether it is, or isn't a relation to Naruto (or even Konoha as a whole), I think the orphan theme in Naruto has to reach a certain conclusion. His is the only lineage which has never once been stated, or even hinted at. In other words, even if the series ends without once challenging this question, my thoughts are that many fans will never be fully satisfied with the series until they discover the "truth" behind the Uzumaki bloodline.

The only thing I can think of which may be (but most likely is not) related to this is the chapter in which Yamato states that Naruto's chakra must be incredibly strong to withstand the poisonous chakra of the Ninetails. It makes me wonder if this "strength" is a trait which may have been passed down to him from his parents. Definitely a long shot though.