It can`t be a comparison, because in order to compare you need two "subjects" to compare, if he said something like... is your eyesight as bad as mine? then it will be completely plausible, kakashi deducted that itachi can`t use mangekyou a lot, becauseOriginally Posted by animus
A) Itachi was tired the first time he used it
B) They even showed a flash of Kisame saying out loud how he shouldn`t be using it or whatever (this one should be enough giveaway...)
Kakashi: After using that technique, you were very fatigued and retreated inmediately
(Flashback) Kisame: Itachi-san, it`s dangerous for you to use your eyes too much
Kakashi: Besides using a large amount of chakra, using that technique poses a huge risk to your eyes right itachi?
I`m focusing in what Kisame said and second part of Kakashi`s last sentence... they basically sayd the same, i don`t see something that needs to be overanalyzed or anything, maybe i`m missing something.