Quote Originally Posted by StillAlive
Maybe the other 9 Akatsuki didn't want Orochimaru to get hold of one of these demons so he left the group blubbering and offended like:
"No you won't become Hokage Oro."
- "Ok. Then I'm going to destroy the village, meanie!"
I know this was mostly meant as a joke, but the reason Orochimaru left the group was because he realized he could not get Itachi. At least that's what I remember him saying to Kabuto. I don't remember the episode.