Isaac getting shot by George after that kind of made sense, but the fact that Isaac threw his gun out right before that scene did not. I just didn't like the tension that existed between the two on account of a lack of trust. Sure, they might not trust each other, but Isaac had a gun, and Dexter had a knife. Moreover, Isaac knew the kinds of things Dexter's "capable" of doing with a knife. So he has the upper hand. No need for him to throw his gun out, which makes the scene he gets shot in, bullshit. It's almost as if Dexter has a superpower that makes people with guns get reeeeeeaaaaaallllly stupid as he approaches them. Infuriates me every time.
The change in behavior I kind of get though. For Deb, she's been bitching for quite some time about this, and came to terms so well with what Dex was doing that she actually tried to put a hit on Hannah. After he refused, she did some more bitching...but you know what? It's time she started getting her act together and picked herself up from that mess and it's good to see her do that. Dexter doesn't want to kill Hanna...yet...fine. She warns Dex as a concerned sister should, and moves on.
Isaac...didn't want to die, and he liked Dexter on a personal level. What would've made the change in behavior more smooth is if they did a better job of showing Isaac coming to an understanding of just why Dexter is the way he is. Then we could see Isaac develop some kind of scruples based respect for Dexter. Then it'd be easier to believe that he could look past Victor's murder...provided Dexter gives him the help he required. I mean...lovers are important and losing them hurts...but if you continue living you might love again.