Quote Originally Posted by Xrlderek
Has anyone got Metal Gear Solid 2 Substance to work on Vista(32bit)?
I got the same problem previously, when I got the game and tried to get it working on my laptop while waiting for the release of MGS4. Tried all methods too, including getting some files from gamecopy.com, but didn't work. Gave up in the end.

Quote Originally Posted by Xrlderek
Also, will I be completely lost if I skip the third game in the series? Please answer without spoilers.
I'm not too sure if Snake Eater is available on the PC, but it IS essential if you want to follow the story. MGS4 reference a lot of events from Snake Eater, and many of the twists and turns in the plot are centered around their characters. Of course you can skip it, but that will only mean that you will be confused by the complex plot continued and concluded by MGS4.