Hmm, looks like next season will definitely have palpable changes, of course House/Wilson dynamic is going to be different; I mean I get Bud's point and all, but I think that painful of a situation is tricky to call. And 13...hmm, well now that she's pretty much received a death sentence, I could see her character going balls to the wall crazy, or like totally inward and introverted...we'll find out next season (although, to be fair, it could literally be decades until the disease causes physical decline and death; usually onset (depending on various factors) in the US and Canada is between 40 and 70).