thing with anime comedy is that some people might not understand the japanese humour, like for example someone falls down as a reaction to something stupid

so i'd really suggest other animes such as action rather than comedy ones

i love family guy and simpsons but if u compare to most animes, cartoons like family guy dont really have a main storyline (its really random) so u'll notice that most animes u really have to watch 1,2,3 every episode or else u miss something

I think the most universal (anyone can watch) anime would be Cowboy Bebop (both subbed and dubbed) so i'd suggest u watch that first,, its alot of action, comedy, drama mix

if u wanna go comedy,, I laughed the most prolly in Tenshi Na Konamaiki (A cheeky Angel) its moslty comedy with a little romance

enjoy! ~